| Autor: |
Teriukova NP, Pogodina ON, Blinova GI, Ivanov VA |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 2011; Vol. 53 (10), pp. 800-7. |
| Abstrakt: |
This study examines the immunomodulating effect of cytostatic drug--cyclophosphamide (Cy)--on natural cytotoxic activity of rats and mice splenocytes. The cytotoxicity of the effector cells against the confluent monolayer cell lines of rat hepatoma Zajdela and HTC and mice hepatoma MH-22a was estimated by means the morphometric analysis. It was shown, that 48 h after single intraperitoneal injection of Cy produced a immunomodulating effect on the activity of splenocytes--suppressor action on cells of Zajdela hepatoma and immunopotentiating action on the target cells of HTC and MH-22a hepatomas. The possible mechanisms of immunopotentiating effect of Cy are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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