Results of a new human recombinant thrombin for the treatment of arterial pseudoaneurysm.

Autor:	Malgor RD; Division of Vascular Surgery, Stony Brook University Medical Center, Stony Brook, NY 11794, USA. rmalgor@sbumed.org, Labropoulos N, Gasparis AP, Landau DS, Tassiopoulos AK
Jazyk:	angličtina
Zdroj:	Vascular and endovascular surgery [Vasc Endovascular Surg] 2012 Feb; Vol. 46 (2), pp. 145-9. Date of Electronic Publication: 2012 Jan 08.
DOI:	10.1177/1538574411431346
Abstrakt:	Objective: To evaluate the results of a new thrombin sealant (Recothrom) for the treatment of arterial pseudoaneurysms (PDAs). Methods: We reviewed 47 consecutive patients prospectively entered in a dedicated data set who underwent ultrasound-guided percutaneous thrombin injection to treat PDA. End points were PDA recurrence, need for reintervention, and related complications such as limb ischemia or allergic reactions. Results: Twenty-six patients were females (55%) and the median age of the entire group was 71 years (range, 45-87). The mean size of the PDA was 2.3 ± 0.9 cm. The mean injected volume was 2.4 ± 1.4 mL containing 500 ± 320 units. Recurrence of the PDA occurred in 4 (8.5%) patients and was not related to anticoagulation status, body habitus, platelets levels, or use of antiplatelets. All recurred PDAs were successfully sealed with a second (n = 3) and a third injection (n = 1). There was no distal embolization or allergic reactions and no surgical intervention was required. Conclusion: The new human recombinant thrombin (Recothrom) is a safer nonimmunogenic option with similar success rates of other fibrin glue sealants.
Databáze:	MEDLINE
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