Human Metapneumovirus in the Cerebrospinal Fluid of a Patient With Acute Encephalitis.

Autor:	Sánchez Fernández I; Department of Child Neurology, Hospital Sant Joan de Déu, Barcelona, Spain. ivan.sanchezfernandez@yahoo.es, Rebollo Polo M, Muñoz-Almagro C, Monfort Carretero L, Fernández Ureña S, Rueda Muñoz A, Colomé Roura R, Pérez Dueñas B
Jazyk:	angličtina
Zdroj:	Archives of neurology [Arch Neurol] 2012 May; Vol. 69 (5), pp. 649-52.
DOI:	10.1001/archneurol.2011.1094
Abstrakt:	Objective: To report, to our knowledge, the first case of detection of human metapneumovirus in the cerebrospinal fluid of a patient during acute encephalitis. Design: Case report. Setting: University hospital. Patient: A 10-year-old girl with acute encephalitis. Results: Human metapneumovirus was detected in cerebrospinal fluid and nasal-wash specimens during the initial phase of mild encephalitis. Abrupt clinical deterioration was associated with the presence of multiple areas of demyelination and cortical abnormalities. Demyelinated areas improved after immunomodulatory therapy, but cortical lesions spread in both hemispheres. Surprisingly, clinical worsening occurred when the virus became undetectable in cerebrospinal fluid. Conclusions: The detection of human metapneumovirus in cerebrospinal fluid strongly suggests its causative role in acute encephalitis. The evolution of the clinical and radiological features provided insight into the pathogenesis of human metapneumovirus encephalitis.
Databáze:	MEDLINE
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