Pediatric donor lungs for adult transplant recipients: feasibility and outcomes.
| Autor: | Keshava HB; Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH 44195, United States., Mason DP, Murthy SC, Brown CR, Pettersson GB |
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| Jazyk: | angličtina |
| Zdroj: | The Thoracic and cardiovascular surgeon [Thorac Cardiovasc Surg] 2012 Jun; Vol. 60 (4), pp. 275-9. Date of Electronic Publication: 2012 Jan 07. |
| DOI: | 10.1055/s-0031-1298063 |
| Abstrakt: | Background: There is a limited experience using pediatric organs for adult lung transplantation (LTx), with size matching the major concern. We reviewed our experience transplanting pediatric donor lungs into adult recipients with endpoints of post-LTx complications and overall patient survival. Methods: From 2/1990 to 12/2007, 609 adults underwent primary LTx at our institution. Thirty-eight (6.2%) patients underwent LTx with organs from pediatric donors (≤16 years). Of these, median donor age was 13 years (range: 7 to 16) and median recipient age 55 (range: 24 to 66). Endpoints analyzed included size matching accuracy, airway and pleural complications, time to extubation, intensive care unit (ICU) and hospital lengths of stay, as well as survival. Results: Gross undersizing of the donor lung was present in 2/38 (5.3%) and of the donor bronchus in 11/38 (29%). Five patients (13%) experienced a major postoperative airway complication. Thoracentesis prior to discharge was necessary in 4/38 (11%) patients and chest tube reinsertion in 10/38 (26%) for pleural effusion. Median time to extubation was 2 days. ICU and hospital lengths of stay were 6 and 16 days, respectively. Kaplan-Meier survival at 30 days, 1 year, 3 years, and 5 years post-transplant was 89%, 74%, 63%, and 55%. Conclusions: Despite sizing concerns, transplantation of pediatric lungs into adult recipients is feasible. Size mismatch may predispose to higher rates of airway and pleural complications. Hospital course and overall survival appear comparable to adult-to-adult LTx, and concerns over size matching should not preclude pediatric organ use for adult candidates. (Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.) |
| Databáze: | MEDLINE |
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