Anticonvulsant action of Calotropis procera latex proteins.

Autor: Lima RC; Instituto Superior de Biomedicina. Universidade Estadual do Ceará, Ceará, Brazil., Silva MC, Aguiar CC, Chaves EM, Dias KC, Macêdo DS, de Sousa FC, Carvalho Kde M, Ramos MV, Vasconcelos SM
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2012 Feb; Vol. 23 (2), pp. 123-6. Date of Electronic Publication: 2012 Jan 09.
DOI: 10.1016/j.yebeh.2011.11.008
Abstrakt: Calotropis procera (Ait.) R.Br. is a laticiferous plant belonging to the Apocynaceae family. C. procera latex proteins were evaluated with respect to anticonvulsant and sedative activity in mouse models of pentylenetetrazol (PTZ)-, pilocarpine-, and strychnine-induced convulsions or turning behavior and pentobarbital-induced sleep. In the strychnine- and pilocarpine-induced seizure models, C. procera latex proteins caused no significant alterations in latencies to convulsions and death, as compared with controls. In the PTZ-induced seizure model, administration of C. procera latex proteins in high doses (50 or 100mg/kg) and diazepam caused significant increases in latencies to convulsions and death. C. procera latex proteins (50 or 100mg/kg) and 2mg/kg diazepam caused a decrease in sleep latency and an increase in sleep time compared with the control group and groups treated with 5 or 10mg/kg. Our results suggest that C. procera latex proteins have a central nervous system-depressant activity as reflected in their potentiation of pentobarbital-induced sleeping time and their anticonvulsant action in the PTZ-induced seizure model.
(Copyright © 2011 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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