Synthesis and DNA cleavage studies of novel quinoline oxime esters.
| Autor: | Bindu PJ; Department of Studies and Research in Chemistry, Kuvempu University, Shankaraghatt 577 451, India. bindu12_naik@rediffmail.com, Mahadevan KM, Satyanarayan ND, Ravikumar Naik TR |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 15; Vol. 22 (2), pp. 898-900. Date of Electronic Publication: 2011 Dec 14. |
| DOI: | 10.1016/j.bmcl.2011.12.037 |
| Abstrakt: | New 2-chloro-3-formyl quinoline oxime esters were synthesized by the reaction of 2-chloro-3-formyl quinoline oximes with various benzoyl chlorides in the presence of triethyl amine and dichloromethane at 0°C. The DNA photo cleavage studies of some new oxime esters were investigated by neutral agarose gel electrophoresis at different concentrations (40μM and 80μM). Analysis of the cleavage products in agarose gel indicated that few of quinoline oxime esters (3d-i) converted into supercoiled pUC19 plasmid DNA to its nicked or linear form. (Copyright © 2011 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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