Metabolic evaluation of young women with congenital adrenal hyperplasia.

Autor:	Schnaider-Rezek GS; Department of Pediatrics, Pediatric Endocrinology Unit, Center for Investigations in Pediatric, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, SP, Brazil., Lemos-Marini SH, Baptista MT, Guerra-Júnior G, Morcillo AM, Mello MP, Oliveira LC, D'Souza-Li L
Jazyk:	angličtina
Zdroj:	Arquivos brasileiros de endocrinologia e metabologia [Arq Bras Endocrinol Metabol] 2011 Nov; Vol. 55 (8), pp. 646-52.
DOI:	10.1590/s0004-27302011000800021
Abstrakt:	Objective: To evaluate insulin resistance and lipid profile in women with congenital adrenal hyperplasia (CAH) caused by classical 21-hydroxylase deficiency (21OHD), and their association with body mass index (BMI) and corticosteroid dosage. Subjects and Methods: We assessed BMI, waist circumference, current glucocorticoid dosage, glucose, insulin and lipid profile in eighteen young women (mean ± SD, 19.3 ± 3.0 years) with 21OHD CAH. Results: BMI was normal in 12 patients, 5 of them were overweight, and 1 was obese. Waist circumference was high in 7 patients. Fasting insulin and HOMA-IR were elevated in seven and eight patients, respectively. Total cholesterol and triglycerides were high in only two patients, and HDL-cholesterol was low in four. Insulin resistance was not associated with BMI, waist circumference or glucocorticoid dose. Conclusions: Young women with 21OHD CAH had infrequent dyslipidemia, but had a higher prevalence of insulin resistance and central obesity, that were independent of BMI or corticosteroid dosage.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu