| Autor: |
Mały E; Department of Medical Diagnostics, Polish Academy of Sciences, Poznań, Poland. ewamaly@gmail.com, Przyborska M, Rybczyńska A, Konatkowska B, Nowak J, Januszkiewicz D |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2012 Apr; Vol. 34 (3), pp. 222-5. |
| DOI: |
10.1097/MPH.0b013e31823321ca |
| Abstrakt: |
The triple association between juvenile xanthogranuloma (JXG), juvenile myelomonocytic leukemia and neurofibromatosis was described in literature in about 20 cases. In this paper, the case of an 11-month-old infant boy with a disseminated JXG with unusual cytogenetic representation in the bone marrow was reported. Neurofibromatosis and juvenile myelomonocytic leukemia were excluded, just the same as other leukemias. Bone marrow and peripheral blood cytogenetic analysis revealed a karyotype with many rearrangements 46,XY,-6,der(12)t(6;12)(p21;p13),del(7)(p13p22),+9 once described in the literature as a B-acute lymphoblastic leukemia case. On the contrary, in our patient immunologic testing demonstrated a high activity of T lymphocytes, however, inflammation was excluded. To the best of our knowledge this is the first described case of systemic JXG with determined karyotype representing unusual chromosomal aberrations. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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