| Autor: |
Mai J; Department of Pharmacology and Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA 19140, USA., Virtue A, Maley E, Tran T, Yin Y, Meng S, Pansuria M, Jiang X, Wang H, Yang XF |
| Jazyk: |
angličtina |
| Zdroj: |
Frontiers in bioscience (Elite edition) [Front Biosci (Elite Ed)] 2012 Jan 01; Vol. 4 (4), pp. 1478-95. Date of Electronic Publication: 2012 Jan 01. |
| DOI: |
10.2741/e474 |
| Abstrakt: |
Interleukin-17 cytokines are a family of pro-inflammatory cytokines. Our current studies found: i) IL-17 cytokines are not ubiquitously expressed, but several receptors and TRAF3IP2 are ubiquitously expressed in tissues with a few exceptions; ii) heart and vascular tissue are in the second tier of readiness to respond to IL-17 cytokine stimulation; iii) alternative transcription starting sites and alternative spliced isoforms are found in IL-17 cytokine and receptor transcripts; iv) higher hypomethylation status is associated with higher expressions of IL-17 receptors; v) the binding sites of several RNA binding proteins are found in the 3'UTRs of the mRNAs of IL-17 cytokines and receptors; and vi) numerous microRNA binding sites are statistically equivalent to that of experimentally verified microRNAs-mRNA interactions in the 3'UTRs of IL-17 cytokine and receptor mRNAs. These results suggest that mechanisms including alternative promoters, alternative splicing, RNA binding proteins, and microRNAs regulate the structures and expressions of IL-17 cytokines and receptors. These results provide an insight into the roles of IL-17 in mediating inflammation and immunity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
