Total synthesis of halichondrin C.
| Autor: | Yamamoto A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA., Ueda A, Brémond P, Tiseni PS, Kishi Y |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the American Chemical Society [J Am Chem Soc] 2012 Jan 18; Vol. 134 (2), pp. 893-6. Date of Electronic Publication: 2011 Dec 23. |
| DOI: | 10.1021/ja2108307 |
| Abstrakt: | The first total synthesis of halichondrin C has been completed, highlighted by development of the synthetic method to construct the C8-C14 polycycle. Cr-mediated coupling reactions are used seven times to form a new C-C bond. The acid stability of halichondrin C is studied, demonstrating that the macrolactone stabilizes the C8-C14 polycycle, relative to the one present in the C1-C16 model. (© 2011 American Chemical Society) |
| Databáze: | MEDLINE |
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