Highly Enantioselective Asymmetric Darzens Reactions with a Phase Transfer Catalyst.

Autor: Liu Y; Department of Chemistry, Brandeis University, Waltham, Massachusetts, 02454, USA., Provencher BA, Bartleson KJ, Deng L
Jazyk: angličtina
Zdroj: Chemical science [Chem Sci] 2011 Jul; Vol. 2 (7), pp. 1301-1304.
DOI: 10.1039/c1sc00137j
Abstrakt: A class of easily accessible and readily tunable chiral phase transfer catalysts based on 6'-OH cinchonium salts was found to efficiently catalyze an unprecedented highly enantioselective Darzens reaction of α-chloro ketones and aldehydes, which directly produces optically active chiral epoxides from readily available carbonyl compounds.
Databáze: MEDLINE