[Pharmacokinetics of phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intravenous injection].

Autor: Chernyshova GA, Smol'iakova VI, Plotnikov MB, Ianovskaia EA, Gurto RV, Udut VV, Kuchin AV, Chukicheva IIu
Jazyk: ruština
Zdroj: Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (9), pp. 20-2.
Abstrakt: The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).
Databáze: MEDLINE