| Autor: |
Samotrueva MA, Tiurenkov IN, Ovcharova AN, Magomedov MM, Khlebtsova EB |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (9), pp. 16-9. |
| Abstrakt: |
Psycho- and immunomodulator activity of GABA(B)-mimetic drug baclofen was studied on Wistar-line rats with the cyclophosphamide-induced immunosuppression and lypopolysaccharide-induced immune stress. It was established that the stimulation of GABA(B) receptors in animals with the immune system hypofunction favors regeneration of the cellular and humoral components of immune response. At the same time, under the conditions of immune hyperreactivity, the modulating effect of baclofen appears only in respect of the cell-mediated immune reaction. Moreover, it was shown that baclofen suppresses psychoemotional disorders that develop under the conditions of cyclophosphamide- and lipopolysaccharide-induced immunopathology. The results obtained in this study confirm that GABA(B) receptors participate in the processes of psycho- and immunomodulation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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