Castor oil polyurethane containing silica nanoparticles as filling material of bone defect in rats.
| Autor: | Nacer RS; Health and Development in the West Central Region, Federal University of Mato Grosso do Sul (UFMS), Campo Grande-MS, Brazil. renatosnacer@gmail.com, Poppi RR, Carvalho Pde T, Silva BA, Odashiro AN, Silva IS, Delben JR, Delben AA |
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| Jazyk: | angličtina |
| Zdroj: | Acta cirurgica brasileira [Acta Cir Bras] 2012 Jan; Vol. 27 (1), pp. 56-62. |
| DOI: | 10.1590/s0102-86502012000100010 |
| Abstrakt: | Purpose: To evaluate the biologic behavior of the castor polymer containing silica nanoparticles as a bone substitute in diafisary defect. Methods: Twenty seven male Rattus norvegicus albinus Wistar lineage were submitted to bone defect filled with castor oil polymer. Three experimental groups had been formed with nine animals each: (1) castor oil polymer containing only calcium carbonate; (2) castor oil polymer with calcium carbonate and doped with 5% of silica nanoparticles; (3) castor polymer with calcium carbonate doped with 10% of silica nanoparticles; 3 animals of each group were submitted to euthanasia 15, 30 and 60 days after experimental procedure, and their femurs were removed to histological evaluation. Results: there was bone growth in all the studied groups, with a greater tendency of growth in the group 1. After 30 days all the groups presented similar results. After 60 days a greater amount of fibroblasts, osteoblasts, osteocytes and osteoclasts in group 3 was observed, with integrated activity of 3 kinds of cells involved in the bone activation-reabsorption-formation. Conclusions: The castor polymer associated to the silica nanoparticles is biocompatible and allows osteoconduction. The presence of osteoprogenitors cells suggests silica osteoinduction capacity. |
| Databáze: | MEDLINE |
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