Histopathologic changes in the uterus, cervix and vagina of immature CD-1 mice exposed to low doses of perfluorooctanoic acid (PFOA) in a uterotrophic assay.

Autor: Dixon D; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: dixon@niehs.nih.gov., Reed CE; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Moore AB; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Gibbs-Flournoy EA; Toxicology Curriculum, University of North Carolina, Chapel Hill, NC 27599, USA., Hines EP; Environmental Media Assessment Group, National Center for Environmental Assessment (NCEA), Office of Research and Development (ORD), U.S. EPA, Research Triangle Park, NC 27711, USA., Wallace EA; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Stanko JP; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Lu Y; Social & Scientific Systems, Inc., Durham, NC 27703, USA., Jefferson WN; Laboratory of Reproductive and Developmental Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Newbold RR; NTP (retired), National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA., Fenton SE; National Toxicology Program (NTP) Laboratories Branch, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: fentonse@niehs.nih.gov.
Jazyk: angličtina
Zdroj: Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2012 Jul; Vol. 33 (4), pp. 506-512. Date of Electronic Publication: 2011 Nov 28.
DOI: 10.1016/j.reprotox.2011.10.011
Abstrakt: The estrogenic and antiestrogenic potential of perfluorooctanoic acid (PFOA) was assessed using an immature mouse uterotrophic assay and by histologic evaluation of the uterus, cervix and vagina following treatment. Female offspring of CD-1 dams were weaned at 18days old and assigned to groups of equal weight, and received 0, 0.01, 0.1, or 1mg PFOA/kg BW/d by gavage with or without 17-β estradiol (E(2), 500μg/kg/d) from PND 18-20 (n=8/treatment/block). At 24h after the third dose (PND 21), uteri were removed and weighed. Absolute and relative uterine weights were significantly increased in the 0.01mg/kg PFOA only group. Characteristic estrogenic changes were present in all E(2)-treated mice; however, they were minimally visible in the 0.01 PFOA only mice. These data suggest that at a low dose PFOA produces minimal histopathologic changes in the reproductive tract of immature female mice, and does not antagonize the histopathologic effects of E(2).
(Published by Elsevier Inc.)
Databáze: MEDLINE
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