[Molecular-biological and antigenic features of H5N1 subtype highly pathogenic influenza virus strains isolated in southern Siberia in 2005-2009].
| Autor: | Sharshov KA, Durymanov AG, Romanovskaia AA, Zaĭkovskaia AV, Marchenko VIu, Silko NIu, Il'inykh FA, Susloparov IM, Alekseev AIu, Shestopalov AM |
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| Jazyk: | ruština |
| Zdroj: | Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2011 Sep-Oct (5), pp. 40-3. |
| Abstrakt: | Aim: Study of molecular-biological and antigenic features of H5N1 subtype virus strains isolated in southern Siberia in 2005-2009. Materials and Methods: Study was performed by using standard procedures according to WHO recommendations. Results: Hemagglutinin gene of H5N1 subtype virus strain isolated in Siberia belongs to 2 genetical lineages: 2.2 and 2.3.2. Strains of these 2 lineages have antigenic differences. All of the strains are highly pathogenic for chicken and white mice. Conclusion: H5N1 subtype highly pathogenic influenza virus variants of 2 different antigenic lineages that have antigenic differences circulated in Siberia in 2005-2009. A possible role of antigenic drift in evolution of H5N1 subtype influenza virus is discussed. |
| Databáze: | MEDLINE |
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