[1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography].
| Autor: | Solà-Bonada N; Servicio de Farmacia, Hospital Clínic, Barcelona, España. solanuria13@hotmail.com, de Andrés-Lázaro AM, Roca-Massa M, Bordas-Alsina JM, Codina-Jané C, Ribas-Sala J |
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| Jazyk: | Spanish; Castilian |
| Zdroj: | Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria [Farm Hosp] 2012 Jul-Aug; Vol. 36 (4), pp. 256-60. Date of Electronic Publication: 2011 Dec 01. |
| DOI: | 10.1016/j.farma.2011.08.003 |
| Abstrakt: | Objectives: Intestinal peristalsis can impede explorations and interventions using retrograde endoscopic cholangiopancreatography. Systemic spasmolytics are frequently employed to reduce this phenomenon, in spite of the adverse anti-cholinergic effects they are associated with. We proposed a formula using 1.6% peppermint oil solution with local use in order to avoid these adverse side effects. Method: We formulated a preparation of 1.6% peppermint oil solution in accordance with the medical literature. The effectiveness of the formula was evaluated in a semi-qualitative manner according to the reduction in peristalsis. Results: We tested two different emulgents, and polysorbate provided the best results. The pilot study carried out with 8 patients demonstrated its effectiveness and safety in reducing intestinal peristalsis. Conclusions: 1.6% peppermint oil solution constitutes an effective and safe alternative to the use of systemic spasmolytics. More studies are needed with a larger sample size in order to establish its usefulness in normal clinical practice. (Copyright © 2011 SEFH. Published by Elsevier Espana. All rights reserved.) |
| Databáze: | MEDLINE |
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