Platelet associated IgG may be related with thrombocytopenia in patients with myelodysplastic syndromes.

Autor: Gilli SC; Hematology and Hemotherapy Center, University of Campinas, Campinas, Brazil. mona@unicamp.br, de Souza Medina S, de Castro V, Fernandes LG, Saad ST
Jazyk: angličtina
Zdroj: Leukemia research [Leuk Res] 2012 May; Vol. 36 (5), pp. 554-9. Date of Electronic Publication: 2011 Nov 29.
DOI: 10.1016/j.leukres.2011.10.003
Abstrakt: Thrombocytopenia is common in patients with myelodysplastic syndromes (MDS) and immune destruction of platelets could be an important factor for its occurrence. We prospectively analyzed platelet-associated IgG (PAIgG) through platelet immunofluorescence test (PIFT), mean platelet volume (MPV), platelet size deviation width (PDW) and glycocalicin index (GCI) of 54 patients with MDS, classified according to the International Prognostic Scoring System (IPSS). Thrombocytopenia (platelet count<100×10(9)/L) was correlated with a higher amount of PAIgG, significantly higher MPV and increased GCI. In addition, worse prognosis IPSS groups were associated with a higher positivity of PIFT, which could be indicative of advanced disease.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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