| Autor: |
Ing EC; Butler Hospital/Alpert Medical School of Brown University, Providence, RI, USA., Bae JW, Maru DS, Altice FL |
| Jazyk: |
angličtina |
| Zdroj: |
AIDS and behavior [AIDS Behav] 2013 Jan; Vol. 17 (1), pp. 113-21. |
| DOI: |
10.1007/s10461-011-0082-0 |
| Abstrakt: |
Patient and regimen persistence in HIV-infected drug users are largely unknown. We evaluated patterns of medication non-persistence among HIV-infected drug users enrolled in a prospective, 6-month randomized controlled trial of directly administered antiretroviral therapy (DAART). Medication-taking behavior was assessed via direct observation and MEMS data. Of 74 participants who initiated DAART, 59 (80%) subjects were non-persistent with medication for 3 or more consecutive days. Thirty-one participants (42%) had 2 or more episodes of non-persistence. Higher depressive symptoms were strongly associated with non-persistence episodes of ≥ 3 days (AOR: 17.4, P = 0.02) and ≥ 7 days AOR: 5.4, P = 0.04). High addiction severity (AOR 3.2, P = 0.03) was correlated with non-persistence ≥ 7 days, and injection drug use (AOR: 15.2, P = 0.02) with recurrence of non-persistence ≥ 3 days. Time to regimen change was shorter for NNRTI-based regimens compared to PI-based ones (HR: 3.0, P = 0.03). There was no significant association between patterns of patient non-persistence and virological outcomes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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