Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads.

Autor: Bigall NC; Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy., Curcio A, Leal MP, Falqui A, Palumberi D, Di Corato R, Albanesi E, Cingolani R, Pellegrino T
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2011 Dec 15; Vol. 23 (47), pp. 5645-50. Date of Electronic Publication: 2011 Nov 18.
DOI: 10.1002/adma.201103505
Abstrakt: Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.
(Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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