The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.

Autor: Cheong SL; Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Singapore 117543, Singapore., Federico S, Venkatesan G, Mandel AL, Shao YM, Moro S, Spalluto G, Pastorin G
Jazyk: angličtina
Zdroj: Medicinal research reviews [Med Res Rev] 2013 Mar; Vol. 33 (2), pp. 235-335. Date of Electronic Publication: 2011 Nov 16.
DOI: 10.1002/med.20254
Abstrakt: Adenosine is an ubiquitous local modulator that regulates various physiological and pathological functions by stimulating four membrane receptors, namely A(1), A(2A), A(2B), and A(3). Among these G protein-coupled receptors, the A(3) subtype is found mainly in the lung, liver, heart, eyes, and brain in our body. It has been associated with cerebroprotection and cardioprotection, as well as modulation of cellular growth upon its selective activation. On the other hand, its inhibition by selective antagonists has been reported to be potentially useful in the treatment of pathological conditions including glaucoma, inflammatory diseases, and cancer. In this review, we focused on the pharmacology and the therapeutic implications of the human (h)A(3) adenosine receptor (AR), together with an overview on the progress of hA(3) AR agonists, antagonists, allosteric modulators, and radioligands, as well as on the recent advances pertaining to the computational approaches (e.g., quantitative structure-activity relationships, homology modeling, molecular docking, and molecular dynamics simulations) applied to the modeling of hA(3) AR and drug design. 
(© 2011 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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