| Autor: |
Hengen N; Bernard J. Dunn School of Pharmacy, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USA., Lizer MH, Kidd RS |
| Jazyk: |
angličtina |
| Zdroj: |
ISRN pharmacology [ISRN Pharmacol] 2011; Vol. 2011, pp. 161740. Date of Electronic Publication: 2011 Aug 14. |
| DOI: |
10.5402/2011/161740 |
| Abstrakt: |
Organic cationic transporter 3 (OCT3, SLS22A3) has only recently emerged as one of the regulators of monoaminergic neurotransmission, which plays a critical role in the pathogenesis of depression and is a potential new antidepressant drug target. OCT3 single-nucleotide polymorphisms (SNPs) have been investigated for their association with psychiatric disorders such as methamphetamine use disorder and obsessive-compulsive disorder in children and adolescents, but not depression. This study was designed to evaluate the allele frequencies of seven OCT3 SNPs in a US Caucasian depressed population and compare these frequencies with a control group of nondepressed subjects. Informed consent and a DNA sample were obtained from 157 subjects and analysis was performed using real-time PCR. Allele and genotype frequencies were compared using a t-test and the Pearson chi-square analysis, respectively. There were no significant differences in OCT3 allele or genotype frequencies between the depressed and non-depressed groups for all seven SNPs evaluated. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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