Synthesis and evaluation of novel analogues of mangiferin as potent antipyretic.
| Autor: | Kant Singh S; Varanasi College of Pharmacy, Uttar Pradesh, Varanasi, India., Sinha SK, Prasad SK, Kumar R, Bithu BS, Sadish Kumar S, Singh P |
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| Jazyk: | angličtina |
| Zdroj: | Asian Pacific journal of tropical medicine [Asian Pac J Trop Med] 2011 Nov; Vol. 4 (11), pp. 866-9. |
| DOI: | 10.1016/S1995-7645(11)60210-1 |
| Abstrakt: | Objective: To screen different analogues of mangiferin pharmacologically for antipyretic activity. Methods: The naturally occurring xanthone glycoside mangiferin was isolated by column chromatography from the ethanolic extract of stem bark of Mangifera indica. Mangiferin was further converted to 5-(N-phenylamino methyleno) mangiferin, 5-(N-p-chlorophenylamino methyleno) mangiferin, 5-(N-2-methyl phenylamino methyleno) mangiferin, 5-(N-p-methoxy phenylamino methyleno) mangiferin, 5-(N, N-diphenylamino methyleno) mangiferin, 5-(N-α-napthylamino methyleno) mangiferin and 5-(N-4-methyl phenylamino methyleno) mangiferin analogues. The synthesized compounds were further screened for antipyretic activity along with mangiferin at a dose level of 100 and 200 mg/kg. Mangiferin and its analogues were characterized by melting point andR(f)value determination and through spectral technique like UV, IR, and NMR spectral analysis. Results: The antipyretic activity of mangiferin as well as all analogues was found to be more significant in at higher dose ie. 200 mg/kg which was depicted through a decrease in rectal temperature up to 3 h. Conclusions: The antipyretic activity of mangiferin and its analogues may be attributed to inhibition in synthesis of TNF-α and anti-oxidant activity associated with amelioration of inflammatory actions of cytokines. (Copyright © 2011 Hainan Medical College. Published by Elsevier B.V. All rights reserved.) |
| Databáze: | MEDLINE |
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