Original report of bilateral carotid body tumors with 2 rare concomitant anatomic findings, an ectopic parathyroid gland and cervical thymus, with literature review.

Autor: Westbrook BJ; Department of Otolaryngology, Madigan Army Medical Center, Tacoma, Washington, USA. benjamin.westbrook@us.army.mil, Harsha WJ, Strenge K
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2013 Mar; Vol. 35 (3), pp. E65-8. Date of Electronic Publication: 2011 Nov 11.
DOI: 10.1002/hed.21876
Abstrakt: Background: Carotid body tumors are uncommon neoplasms with unique epidemiology and management demands. Cervical embryology is complex. Developmental abnormalities can result in ectopic displacement of native tissues.
Methods: We present the case of a 21-year-old female with bilateral carotid body paragangliomas who presented to our clinic seeking excision of the symptomatic right-sided tumor.
Results: The patient was successfully treated with surgical excision. Two rare anatomic variants were identified in her surgical specimen: a carotid sheath parathyroid gland and ectopic thymus tissue.
Conclusions: This patient represents an unreported combination of pathologic and anatomic phenomena. The paraganglioma resulted from a familial genetic mutation that is well studied in this patient's ethnic population (Dutch), and the literature on this topic is reviewed herein. The 2 anatomic variants likely represent a single, embryologic glitch that will carry no physiologic sequelae. The clinical application of this ectopic anatomy and the common embryologic origins are discussed.
(Copyright © 2011 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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