[Studies of mutagenic activity of positively charged alkyl glycerolipids in Ames test].

Autor: Romanova SG, Belitskiĭ GA, Khitrovo IA, Serebrennikova GA, Shtil' AA
Jazyk: ruština
Zdroj: Biomeditsinskaia khimiia [Biomed Khim] 2011 Jul-Aug; Vol. 57 (4), pp. 429-34.
DOI: 10.18097/pbmc20115704429
Abstrakt: Mutagenic activity of non-phosphorous cationic alkyl glycerolipid rac-N-{4-[(2-Methoxy-3-octadecyloxy)propyl]oxycarbonylbutyl}-N,N-dimethyl-N-(2-hydroxyethyl) ammonium iodide was evaluated. According performed Ames assay results indicated on non-mutagenic properties tested compound. Resulting data open the possibility to carry out biological study in vivo for class of ether cationic glycerolipids and further applications as a potential agent of anticancer therapy.
Databáze: MEDLINE