Can we use a lower dose of liposomal amphotericin B for the treatment of mucosal American leishmaniasis?

Autor: Amato VS; Division of Infectious and Parasitic Diseases, Hospital das Clínicas, University of São Paulo, Medical School, Brazil. valdirsa@netpoint.com.br, Tuon FF, Camargo RA, Souza RM, Santos CR, Nicodemo AC
Jazyk: angličtina
Zdroj: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2011 Nov; Vol. 85 (5), pp. 818-9.
DOI: 10.4269/ajtmh.2011.11-0287
Abstrakt: Liposomal amphotericin B has been used as an alternative treatment of mucosal leishmaniasis, but the optimal dose is not established. We retrospectively reviewed the clinical outcome of eight patients with mucosal leishmaniasis treated with liposomal amphotericin B. The mean total dose was 35 mg/kg (range 24-50 mg/kg), which resulted in the healing of all the lesions in all patients and no recurrences were observed during the follow-up period (mean 25 months; range 7-40 months).
Databáze: MEDLINE