| Autor: |
Subramoniam A; Phytochemistry and Phytopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Thiruvananthapuram District, Pin: 695562, India. asubramoniam@yahoo.com, Asha VV, Nair SA, Sasidharan SP, Sureshkumar PK, Rajendran KN, Karunagaran D, Ramalingam K |
| Jazyk: |
angličtina |
| Zdroj: |
Inflammation [Inflammation] 2012 Jun; Vol. 35 (3), pp. 959-66. |
| DOI: |
10.1007/s10753-011-9399-0 |
| Abstrakt: |
In view of the folklore use of green leaves to treat inflammation, the anti-inflammatory property of chlorophylls and their degradation products were studied. Chlorophyll a and pheophytin a (magnesium-free chlorophyll a) from fresh leaves showed potent anti-inflammatory activity against carrageenan-induced paw edema in mice and formalin-induced paw edema in rats. Chlorophyll a inhibited bacterial lipopolysaccharide-induced TNF-α (a pro-inflammatory cytokine) gene expression in HEK293 cells, but it did not influence the expression of inducible nitric acid synthase and cyclooxygenase-2 genes. Chlorophyll b only marginally inhibited both inflammation and TNF-α gene expression. But both chlorophyll a and chlorophyll b showed the same level of marginal inhibition on 12-O-tetradecanoyl-phorbol-13-acetate-induced NF-κB activation. Chlorophylls and pheophytins showed in vitro anti-oxidant activity. The study shows that chlorophyll a and its degradation products are valuable and abundantly available anti-inflammatory agents and promising for the development of phytomedicine or conventional medicine to treat inflammation and related diseases. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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