Combination of the Framingham risk score and carotid intima-media thickness improves the prediction of cardiovascular events in patients with type 2 diabetes.
| Autor: | Yoshida M; Department of Medicine, Metabolism, and Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan., Mita T, Yamamoto R, Shimizu T, Ikeda F, Ohmura C, Kanazawa A, Hirose T, Kawamori R, Watada H |
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| Jazyk: | angličtina |
| Zdroj: | Diabetes care [Diabetes Care] 2012 Jan; Vol. 35 (1), pp. 178-80. Date of Electronic Publication: 2011 Oct 25. |
| DOI: | 10.2337/dc11-1333 |
| Abstrakt: | Objective: The aim of this study was to investigate whether carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV) add value to the Framingham risk score (FRS) in predicting the development of cardiovascular diseases (CVDs) in type 2 diabetic patients with a negative history of CVD. Research Design and Methods: Type 2 diabetic patients (n = 783) were retrospectively recruited and followed for CVD. Results: During a 5.4-year follow-up period, 85 incidences of CVD were recorded (10.9%). After adjustment for conventional arterial risk factors, multivariate analysis with the Cox proportional hazards model identified IMT, but not baPWV, as a significant determinant of CVD. In addition, the combination of FRS with IMT, but not with baPWV, improved the prediction of CVD. Conclusions: Carotid IMT is a significant predictor of CVD in asymptomatic type 2 diabetic patients, and the combination of FRS and IMT improves the prediction of CVD in these patients. |
| Databáze: | MEDLINE |
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