Circulating neuregulin-1β levels vary according to the angiographic severity of coronary artery disease and ischemia.
| Autor: | Geisberg CA; Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA. carrie.geisberg@vanderbilt.edu, Wang G, Safa RN, Smith HM, Anderson B, Peng XY, Veerkamp B, Zhao DX, Blakemore D, Yu C, Sawyer DB |
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| Jazyk: | angličtina |
| Zdroj: | Coronary artery disease [Coron Artery Dis] 2011 Dec; Vol. 22 (8), pp. 577-82. |
| DOI: | 10.1097/MCA.0b013e32834d3346 |
| Abstrakt: | Background: Coronary artery disease (CAD) is the leading killer in the United States. Patients with severe CAD and ischemia have worse prognosis. Therefore expansion of biomarker research, to identify at-risk individuals and explain the complex biology between cardiovascular growth factors and atherosclerosis is needed. Neuregulin-1β (NRG-1β) is a myocardial stress activated growth and survival factor released from endocardial and endothelial cells. NRG-1β is essential for cardiovascular development and a regulator of angiogenesis. We postulated that plasma and serum levels of NRG-1β would vary in relation to CAD severity and the presence of stress-induced ischemia. Methods: We measured serum and plasma levels of NRG-1β and vascular endothelial growth factor (VEGF) in 60 patients undergoing cardiac catheterization. CAD severity was calculated from angiographic results using a modified Duke jeopardy score. Results: Serum NRG-1β (sNRG-1β), plasma NRG-1β (pNRG-1β), serum VEGF, and plasma VEGF were detectable in the majority of patients. The pNRG-1β levels were approximately two-fold higher than sNRG-1β. Both sNRG-1β and pNRG-1β correlated inversely with CAD severity. pNRG-1β levels were statistically higher in patients with stress-induced ischemia denoted by a positive myocardial perfusion imaging study that correlated with angiographic findings (P=0.02). Conclusion: Both sNRG-1β and pNRG-1β correlated inversely with angiographic severity of CAD. pNRG-1β levels were two-fold higher than serum and were higher in patients with stress-induced ischemia. Therefore we conclude that plasma is the optimal source for the further exploration of the biological significance of NRG-1β as a biomarker of CAD severity and ischemia. (© 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins) |
| Databáze: | MEDLINE |
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