| Autor: |
Albalat-Serradeil M; Clariant France, Usine de Lamotte, LRA, 60350 Trosly Breuil, France., Primazot G, Wilhelm D, Vallejos JC, Vanthuyne N, Roussel C |
| Jazyk: |
angličtina |
| Zdroj: |
Amino acids [Amino Acids] 2012 Aug; Vol. 43 (2), pp. 687-96. Date of Electronic Publication: 2011 Oct 21. |
| DOI: |
10.1007/s00726-011-1117-6 |
| Abstrakt: |
The first successful resolution of rac-α-aminoacetals via diastereoisomeric salt formation with optically pure N-protected aminoacids is reported. The absolute configuration assignment of α-aminoacetal enantiomers is performed by an entirely non-racemizing chemical correlation method involving N-protection and a new efficient hydrolysis step followed by a reduction of the resulting N-protected α-aminoaldehyde intermediates. A racemization method of optically enriched α-aminoacetals is exemplified to allow valorisation of both enantiomers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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