Autor: |
Wong NS; Duke University Medical Center, Durham, North Carolina, USA., Meadows KL, Rosen LS, Adjei AA, Kaufmann SH, Morse MA, Petros WP, Zhu Y, Statkevich P, Cutler DL, Meyers ML, Hurwitz HI |
Jazyk: |
angličtina |
Zdroj: |
Cancer investigation [Cancer Invest] 2011 Nov; Vol. 29 (9), pp. 617-25. |
DOI: |
10.3109/07357907.2011.621912 |
Abstrakt: |
We conducted a phase I study to assess safety, pharmacokinetics, pharmacodynamics, and activity of lonafarnib plus gemcitabine. Subjects received oral lonafarnib twice daily and gemcitabine on days 1, 8, and 15 every 28 days; multiple dose levels were explored. Lonafarnib had no apparent effect on gemcitabine PK. Mean lonafarnib half-life ranged from 4 to 7 hr; median T(max) values ranged from 4 to 8 hr. Two patients had partial response; seven patients had stable disease at least 6 months. Oral lonafarnib at 150 mg a.m./100 mg p.m. plus gemcitabine at 1,000 mg/m(2) is the maximum tolerated dose with acceptable safety and tolerability. |
Databáze: |
MEDLINE |
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