Usabamycins A-C: new anthramycin-type analogues from a marine-derived actinomycete.
| Autor: | Sato S; Central Research Laboratory, Tokyo Innovation Center, Nippon Suisan Kaisha, Ltd, Hachioji, Tokyo, Japan. s-satou@nissui.co.jp, Iwata F, Yamada S, Kawahara H, Katayama M |
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| Jazyk: | angličtina |
| Zdroj: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Dec 01; Vol. 21 (23), pp. 7099-101. Date of Electronic Publication: 2011 Sep 25. |
| DOI: | 10.1016/j.bmcl.2011.09.086 |
| Abstrakt: | New anthramycin-type analogues, designated usabamycin A-C (1, 2 and 3), have been isolated from cultures of Streptomyces sp. NPS853, a bacterium found in marine sediments. The structures of the new compounds were established on the basis of extensive spectroscopic analyses including 1D- and 2D-NMR ((1)H-(1)H COSY, HSQC, and HMBC) experiments. The usabamycins show weak inhibition of HeLa cell growth and selective inhibition of serotonin (5-hydroxytrypamine) 5-HT(2B) uptake. (Copyright © 2011 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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