| Autor: |
Assem M; Departments of Hepatology and Gastroenterology, National Liver Institute, Monoufiya University, Sheben Al kom 3211, Egypt., Yousri M |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of hepatology [Int J Hepatol] 2011; Vol. 2011, pp. 530949. Date of Electronic Publication: 2011 May 14. |
| DOI: |
10.4061/2011/530949 |
| Abstrakt: |
Background/Aim. We evaluate the impact of combined pentoxifylline and high-dose vitamins E to standard antiviral treatment on RBV-induced haemolytic anaemia. Patients and Methods. Selected 200 naïve chronic HCV patients, were randomized to receive either the standard antiviral therapy (peginterferon α-2b and RBV) plus pentoxifylline (800 mg) and high-dose vitamin E (1000 iu) daily (combined group) or received standard antiviral therapy plus placebo only (control group). They were followed up during treatment course and for 6 months posttreatment to assess the occurrence of anaemia and virological response, respectively. Results. RBV dose modification due to anaemia were significantly less in combined group (8.5 versus 21.5%. P < .05).Withdrawal, secondary to sever anemia (Hb < 8.5 gm%), was recorded only in 6 (28.6%) patients of the control group. Both (ETR) and (SVR) were significantly higher in combined group than control group by both intention-to-treat analysis (71 versus 56%, P < .05 and 66 versus 49%, P < .05) and per-protocol analysis (85.5 versus 70.9%, P < .05 and 79.5 versus 62%, P < .05). Conclusion. Pentoxifylline and vitamin E can ameliorate RBV-associated haemolysis; improve compliance and virologic clearance when combined with the standard antiviral therapy in patients with chronic hepatitis C. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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