Adiponectin as a marker of complications in type I diabetes.

Autor: Habeeb NM; Department of Pediatrics, Ain Shams University, Cairo, Egypt., Youssef OI, Saab AA, El Hadidi ES
Jazyk: angličtina
Zdroj: Indian pediatrics [Indian Pediatr] 2012 Apr; Vol. 49 (4), pp. 277-80. Date of Electronic Publication: 2011 Aug 15.
DOI: 10.1007/s13312-012-0041-5
Abstrakt: Objective: To evaluate adiponectin levels in children and adolescents with type I diabetes, and their relationship to long term complications.
Design: Cross sectional.
Setting: Tertiary referral hospital, Cairo, Egypt.
Participants: Thirty children and adolescents with type I diabetes mellitus, classified into complicated and non-complicated and compared to 10 healthy age and sex matched subjects as a control group.
Methods: All children underwent anthropometric measurements, neurological assessment, fundus examination, echocardiography and assays of HbA1c, creatinine, 24-hr urinary protein, and serum adiponectin.
Main Outcome Measure: Relationship of serum adiponectin to complications of type I diabetes mellitus, and glucose control.
Results: Serum adiponectin was significantly elevated in complicated diabetes (10.3 ± 5.9 pg/dL) as compared to the controls (6.5 ± 3.7 pg/dL) (P<0.01), and correlated directly with HbA1c (P<0.05) and creatinine (P<0.001). Patients with nephropathy showed high values of adiponectin (15.7 ± 3.7 pg/dL).
Conclusion: Elevated adiponectin level in children and adolescents with type I diabetes indicates poor glycemic control and development of complications, especially nephropathy.
Databáze: MEDLINE
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