Transcription of Aspergillus nidulans pacC is modulated by alternative RNA splicing of palB.

Autor: Trevisan GL; Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900 Ribeirão Preto, SP, Brazil., Oliveira EH, Peres NT, Cruz AH, Martinez-Rossi NM, Rossi A
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 2011 Nov 04; Vol. 585 (21), pp. 3442-5. Date of Electronic Publication: 2011 Oct 05.
DOI: 10.1016/j.febslet.2011.09.037
Abstrakt: Fungi have evolved elaborate signal transduction networks for remodeling metabolic pathways to scavenge nutrients, including the secretion of nutritional enzymes. This adaptive response involves the conserved PacC/Pal signal transduction pathway, which mediates the transcriptional response to ambient pH. In this study, we show that transcription of the gene for PacC is modulated in response to nutrient changes, phosphate and carbon sources, and pH. In addition, we show that transcription of pacC is modulated in response to alternative RNA splicing of the palB gene. These results reveal novel aspects of the complex network involved in modulation of pacC.
(Copyright © 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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