Inhibition of nonmammalian glycosidases by azetidine iminosugars derived from stable 3,5-di-O-triflates of pentoses.
| Autor: | Lenagh-Snow GM; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK., Araujo N, Jenkinson SF, Rutherford C, Nakagawa S, Kato A, Yu CY, Weymouth-Wilson AC, Fleet GW |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2011 Nov 04; Vol. 13 (21), pp. 5834-7. Date of Electronic Publication: 2011 Oct 10. |
| DOI: | 10.1021/ol2024482 |
| Abstrakt: | Efficient ring closure of stable crystalline 3,5-di-O-triflates of pentofuranosides with amines to form azetidines allowed preliminary evaluation of four-ring iminosugars as glycosidase inhibitors; significant and specific inhibition of nonmammalian α-glucosidases is shown by L-xylo- and L-arabino-iminosugar azetidines. (© 2011 American Chemical Society) |
| Databáze: | MEDLINE |
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