| Autor: |
Avramova BE; Specialized Hospital for Treatment of Children with Onco-Haematological Diseases, Sofia, Bulgaria. b.avramova@sbaldohz.com, Yordanova MN, Konstantinov DN, Bobev DG |
| Jazyk: |
angličtina |
| Zdroj: |
Drug design, development and therapy [Drug Des Devel Ther] 2011; Vol. 5, pp. 407-9. Date of Electronic Publication: 2011 Aug 26. |
| DOI: |
10.2147/DDDT.S19157 |
| Abstrakt: |
This paper describes the successful mobilization of peripheral blood stem cells for autologous transplantation in three children with malignant diseases by using plerixafor (Mozobil; Genzyme Corporation, Cambridge, MA) and granulocyte-colony stimulating factor (G-CSF) after failed previous mobilizations. A median sixfold increase in the number of circulating CD34+ cells after plerixafor treatment as compared with the baseline level was observed. An optimal CD34+ cell count for transplantation with one or two leukapheresis sessions was achieved. Mobilization using plerixafor was found to be safe with no adverse events. Therefore, the combination of G-CSF and plerixafor in children results in effective increases in peripheral CD34+ cell counts and reduces the risk of mobilization failure. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
