[Changes the TRPV1-immunoreactive neurons of the rat spinal nerve sensory ganglia induced by capsaicin].

Autor: Porseva VV, Shilkin VV, Korzina MB, Korobkin AA, Masliukov PM
Jazyk: ruština
Zdroj: Morfologiia (Saint Petersburg, Russia) [Morfologiia] 2011; Vol. 139 (3), pp. 41-5.
Abstrakt: Morphological features of the TRPV1-immunoreactive neurons were studied in thoracic spinal nerve sensory ganglion in 10-, 20-, 30-, 60- and 90-day-old rats under normal conditions and after chemical deafferentation caused by capsaicin (100 mg/kg) subcutaneous injection at postnatal day 2. TRPV1-immunoreactive neurons differed in their morphometric characteristics: positive neurons had very small and small sizes, negative cells had the small, medium and large sizes. Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation.
Databáze: MEDLINE