Design and synthesis of novel diphenyl oxalamide and diphenyl acetamide derivatives as anticonvulsants.

Autor: Nikalje AP; Department of Pharmaceutical Chemistry, Y.B. Chavan College of Pharmacy, Aurangabad (M.S.), India. ana@k.st, Ghodke M, Girbane A
Jazyk: angličtina
Zdroj: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2012 Jan; Vol. 345 (1), pp. 57-64. Date of Electronic Publication: 2011 Sep 23.
DOI: 10.1002/ardp.201100108
Abstrakt: A series of novel N(1) -substituted-N(2) ,N(2) -diphenyl oxalamides 3a-l were synthesized in good yield by stirring diphenylcarbamoyl formyl chloride (2) and various substituted aliphatic, alicyclic, aromatic, heterocyclic amines in DMF and K(2) CO(3) . Also 2-substituted amino-N,N-diphenylacetamides 5a-m were designed by pharmacophore generation and synthesized by stirring 2-chloro-N,N-diphenylacetamide (4) and various substituted amines in acetone using triethyl amine as a catalyst. All the synthesized compounds were screened for anticonvulsant activity in Swiss albino mice by MES and ScPTZ induced seizure tests. Neurotoxicity screening and behavioral testing was also carried out. Some of the synthesized test compounds were found to be more potent than the standard drug.
(Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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