Immune response of 23-valent pneumococcal polysaccharide vaccinated elderly and its relation to frailty indices, nutritional status, and serum zinc levels.

Autor: Hamza SA; Department of Geriatrics and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Mousa SM, Taha SE, Adel LA, Samaha HE, Hussein DA
Jazyk: angličtina
Zdroj: Geriatrics & gerontology international [Geriatr Gerontol Int] 2012 Apr; Vol. 12 (2), pp. 223-9. Date of Electronic Publication: 2011 Sep 26.
DOI: 10.1111/j.1447-0594.2011.00749.x
Abstrakt: Aim: To detect the immunoglobulin M memory B cell population response following vaccination with the 23-valent pneumococcal polysaccharide vaccine and determine its relation to frailty indices, nutritional status, and serum zinc levels.
Methods: A cross-sectional study was carried out in the outpatient geriatric clinic, Ain Shams University Hospital. It included 80 community-dwelling elderly, 32 male and 48 female. Each participant underwent vaccination with the 23-valent pneumococcal polysaccharide vaccine, comprehensive geriatric assessment, nutritional assessment with the DETERMINE check list, frailty indices assessment, and serum zinc level measurement. The percentage of immunoglobulin M memory B cells was evaluated before and 4 weeks after vaccination. Immune response was calculated as the difference between cell percentage before and after vaccination.
Results: Before the vaccination, the immunoglobulin M memory B cell percentage was significantly lower among those eating fewer than two meals a day and taking three or more drugs a day; after vaccination significance was observed among those with tooth or mouth problems that make eating difficult. Immune response was significantly lower among those with tooth or mouth problems (P < 0.001), weight loss (P < 0.001), shrinking (P = 0.001), poor endurance (P = 0.04), multiple comorbidities (P = 0.013), and cognitive impairment (P = 0.001). Participants with immune response ≥10% showed significantly higher serum zinc levels compared to those with immune response <10% of increase in cell percentage.
Conclusion: Poor nutritional status, frailty and a lower zinc level impair the immunological response of elderly individuals.
(© 2011 Japan Geriatrics Society.)
Databáze: MEDLINE
Externí odkaz: