Effects of lycopene on oxidative stress and remnant liver histology after partial hepatectomy in rats.

Autor:	Aytac E; Department of 1General Surgery, ‹stanbul University, Cerrahpasa Medical School, Istanbul, Turkey. eaytactr@yahoo.com, Ayan F, Saygili S, Genç H, Karaca C, Bayrak I, Uzun H, Salıhoğlu Z, Erdamar S, Sözer V, Altuğ T, Seymen P, Seymen HO
Jazyk:	angličtina
Zdroj:	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology [Turk J Gastroenterol] 2011 Aug; Vol. 22 (4), pp. 408-13.
DOI:	10.4318/tjg.2011.0189
Abstrakt:	Background/aims: Partial hepatectomy is performed for the treatment of mass lesions in the liver. Lycopene, which is a carotenoid, is present in various physiologic processes. In this study, the effects of lycopene administration in partially hepatectomized rats were evaluated by assessing various oxidant/antioxidant parameters, remnant liver histology and plasma nitric oxide levels. Methods: Thirty Wistar albino adult male rats were randomly divided into three equal groups as: Sham, Partial Hepatectomy and Lycopene-Administered + Partial Hepatectomy groups. Lycopene (4 mg/kg), which was dissolved in olive oil, was given to the rats per orally (via gavage tube) (0.1 ml) every day for 6 weeks before partial hepatectomy and for one week after partial hepatectomy. Tissue and blood samples were collected one week after partial hepatectomy. Results: Plasma malondialdehyde (p<0.001) and nitric oxide (p<0.05) levels in the lycopene-administered + partial hepatectomy group were significantly higher than in the partial hepatectomy group. Intraerythrocytic glutathione (p<0.001), plasma (p<0.001) and liver tissue Cu-Zn (p<0.05) superoxide dismutase levels of the lycopene-administered + partial hepatectomy group were significantly lower than in the partial hepatectomy group. Conclusions: Lycopene administration could be harmful by increasing oxidative stress after partial hepatectomy.
Databáze:	MEDLINE
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