DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response.
| Autor: | Granot E; Department of Pediatrics, Kaplan Medical Center, P.O. Box 1, Rehovot, Israel. ettie_g@clalit.org.il, Jakobovich E, Rabinowitz R, Levy P, Schlesinger M |
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| Jazyk: | angličtina |
| Zdroj: | Mediators of inflammation [Mediators Inflamm] 2011; Vol. 2011, pp. 493925. Date of Electronic Publication: 2011 Sep 18. |
| DOI: | 10.1155/2011/493925 |
| Abstrakt: | Background: It is currently recommended that diet of pregnant mothers contain 200-300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. Methods: 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. Results: CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN(γ) significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. Conclusions: In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFN(γ) production is compatible with attenuation of a proinflammatory response. |
| Databáze: | MEDLINE |
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