| Autor: |
Cervigón-González I; Dermatology and Anatomical Pathology Unit, Hospital Nuestra Señora del Prado, Talavera de la Reina, Spain., Torres-Iglesias LM, Palomo-Arellano A, Gil-Pascual B |
| Jazyk: |
angličtina |
| Zdroj: |
Case reports in dermatology [Case Rep Dermatol] 2011 Jan; Vol. 3 (1), pp. 13-7. Date of Electronic Publication: 2011 Feb 05. |
| DOI: |
10.1159/000324185 |
| Abstrakt: |
Advanced-stage primary cutaneous T-cell lymphoma has an unfavorable prognosis and low survival rates. Aggressive treatment with chemotherapy is not curative and causes considerable side effects. The combination of bexarotene and denileukin diftitox is associated with an acceptable safety profile and a likely synergistic effect because bexarotene is capable of modulating expression of IL-2 receptor and enhance the susceptibility of T-cell leukemia cells to denileukin diftitox. In the case reported here, the response to this combined treatment was satisfactory and well tolerated. The patient showed a complete regression of pruritus, restlessness, and insomnia. Skin lesions improved partially, and lymphadenopathy was reduced and finally disappeared completely. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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