Confirmed swine-origin influenza A(H1N1) viral pneumonia: computed tomographic findings in the immunocompetent and the immunocompromised.

Autor:	Chandler TM; Department of Radiology, Vancouver General Hospital, Vancouver, British Columbia, Canada. chandler.tracy@gmail.com, Leipsic J, Nicolaou S, Quiney B, Romney M, Müller NL, Ajlan AM
Jazyk:	angličtina
Zdroj:	Journal of computer assisted tomography [J Comput Assist Tomogr] 2011 Sep-Oct; Vol. 35 (5), pp. 602-7.
DOI:	10.1097/RCT.0b013e31822c56f1
Abstrakt:	Aim: This study aimed to retrospectively evaluate the computed tomographic (CT) appearance of cases of swine-origin influenza A(H1N1) viral infection (S-OIV) in immunocompetent and immunocompromised patients confirmed with reverse transcription-polymerase chain reaction and to determine whether the timing of CT relative to the onset of symptoms affected the overall imaging appearance [corrected]. Methods: A total of 23 patients (15 men and 8 women) from 2 tertiary care centers formed the final study population. Patients were divided into 2 groups based on their immune status: group 1 (n = 14) were patients who were immunocompromised, whereas group 2 (n = 9) were patients who were immunocompetent. The radiologic appearances of pulmonary abnormalities, distribution, and extent of involvement on the initial chest CT scan were documented, and correlation with the onset of symptoms was performed. Results: The most common CT pattern in both groups of S-OIV patients was ground-glass opacities and consolidation (group 1, 86%; group 2, 71%) in a bilateral, subpleural, and peribronchovascular pattern. Small airways disease [corrected] was seen only in a minority of patients (group 1, 7%; group 2, 11%. Onset of symptoms to time of CT showed a mean duration of 9.7 days in group 1 and 6.7 days in group 2 and did not affect the overall imaging appearance. Conclusions: The most common abnormalities on CT scans of both immunocompetent and immunocompromised S-OIV patients were ground-glass opacities and consolidation in a bilateral, subpleural, and peribronchovascular distribution, resembling organizing pneumonia. This appearance was seen regardless of the timing of CT relative to the onset of symptoms.
Databáze:	MEDLINE
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