| Autor: |
Vilotti S; Sector of Neurobiology, International School for Advanced Studies, Via Bonomea 265, Trieste, Italy., Biagioli M, Foti R, Dal Ferro M, Lavina ZS, Collavin L, Del Sal G, Zucchelli S, Gustincich S |
| Jazyk: |
angličtina |
| Zdroj: |
Cell death and differentiation [Cell Death Differ] 2012 Mar; Vol. 19 (3), pp. 488-500. Date of Electronic Publication: 2011 Sep 16. |
| DOI: |
10.1038/cdd.2011.118 |
| Abstrakt: |
TRAF and TNF receptor-associated protein (TTRAP) is a multifunctional protein that can act in the nucleus as a 5'-tyrosyl DNA phosphodiesterase and in the cytoplasm as a regulator of cell signaling. In this paper we show that in response to proteasome inhibition TTRAP accumulates in nucleolar cavities in a promyelocytic leukemia protein-dependent manner. In the nucleolus, TTRAP contributes to control levels of ribosomal RNA precursor and processing intermediates, and this phenotype is independent from its 5'-tyrosyl DNA phosphodiesterase activity. Our findings suggest a previously unidentified function for TTRAP and nucleolar cavities in ribosome biogenesis under stress. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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