| Autor: |
Nogueira FH; Universidade Federal de Minas Gerais, Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Av. Pres. Antônio Carlos 6627, Sala 4029 Bloco 2, 31270-901, Belo Horizonte, MG, Brazil. fhanogueira@gmail.com, Goulart Lde P, César Ida C, de Campos LM, Pianetti GA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of AOAC International [J AOAC Int] 2011 Jul-Aug; Vol. 94 (4), pp. 1089-93. |
| Abstrakt: |
A simple HPLC method for determination of mefloquine hydrochloride in tablets was developed and validated. The separation was carried out on an Xterra RP18 (250 x 4.6 mm id, 5 pm particle size) analytical column. The mobile phase was 0.05 M monobasic potassium phosphate buffer (pH 3.5)-methanol (40 + 60, v/v). The flow rate and wavelength were set to 1 mL/min and 283 nm, respectively. The method was specific for mefloquine hydrochloride in the presence of hydrolytic, oxidative, and photolytic degradation products. It was also linear, precise, accurate, and robust, being suitable for routine QC analyses and stability studies. The developed HPLC method was compared to a previously described spectrophotometric method. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
