| Autor: |
Berkowitz RS; New England Trophoblastic Disease Center, Fearing Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115., Faris HM, Hill JA, Anderson DJ |
| Jazyk: |
angličtina |
| Zdroj: |
Gynecologic oncology [Gynecol Oncol] 1990 Jun; Vol. 37 (3), pp. 396-400. |
| DOI: |
10.1016/0090-8258(90)90375-u |
| Abstrakt: |
Monoclonal antibodies were used to localize and characterize leukocytes and cytokines in chorionic villi of normal placenta and complete mole. OKT4a reacted with Hofbauer cells in first-, second-, and third-trimester placentas. HLA-DR was expressed on second- and third-trimester placental Hofbauer cells but was not detected in the first trimester. The cytokines, gamma-interferon, granulocyte-macrophage colony-stimulating factor, interleukin-1 alpha, and tumor necrosis factor alpha, were all detectable on Hofbauer cells in first-, second-, and third-trimester placentas. None of the tested cytokine antibodies reacted with cellular constituents in complete molar chorionic villi. The absence of cytokine-positive cells in molar chorionic villi may be related to the hyperplastic and unregulated growth of molar villous trophoblast. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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