| Autor: |
Bastrygin DV, Viglinskaia AO, Kolyvanov GB, Litvin AA, Bochkov PO, Mozhaeva TIa, Zherdev VP |
| Jazyk: |
ruština |
| Zdroj: |
Eksperimental'naia i klinicheskaia farmakologiia [Eksp Klin Farmakol] 2011; Vol. 74 (7), pp. 22-6. |
| Abstrakt: |
Pharmacokinetics of compound M-11 (main metabolite of afobazole) after administration via different routes was studied in rats. After oral and intravenous administration, M-11 exhibited weakly pronounced bioconversion with the formation of a few metabolites that could be detected in plasma samples for about 3 hours. The absolute bioavailability of M-11 after oral administration was 68.3%. It was found that M-11 was completely absorbed from gastrointestinal tract of rats and characterized by "the first pass effect", after which approximately 70% of administered dose entered the circulation. The parent substance was determined neither in urine nor in feces. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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