Evaluation of olestra in short-term genotoxicity assays.

Autor: Skare KL; Procter & Gamble Company, Shelton, CT 06484., Skare JA, Thompson ED
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1990 Feb; Vol. 28 (2), pp. 69-73.
DOI: 10.1016/0278-6915(90)90012-c
Abstrakt: Olestra, a mixture of hexa-, hepta- and octa-esters formed from the reaction of sucrose with long-chain fatty acids, was evaluated for its genotoxic potential in the Salmonella/mammalian microsome test, the L5178Y thymidine kinase (TK+/-) mouse lymphoma assay, an unscheduled DNA synthesis assay in primary rat hepatocytes, and an in vitro cytogenetic assay in Chinese hamster ovary cells. The results indicated that olestra was non-genotoxic in these assays.
Databáze: MEDLINE