Genetic mouse models relevant to schizophrenia: taking stock and looking forward.

Autor: Harrison PJ; Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK. paul.harrison@psych.ox.ac.uk, Pritchett D, Stumpenhorst K, Betts JF, Nissen W, Schweimer J, Lane T, Burnet PW, Lamsa KP, Sharp T, Bannerman DM, Tunbridge EM
Jazyk: angličtina
Zdroj: Neuropharmacology [Neuropharmacology] 2012 Mar; Vol. 62 (3), pp. 1164-7. Date of Electronic Publication: 2011 Aug 16.
DOI: 10.1016/j.neuropharm.2011.08.009
Abstrakt: Genetic mouse models relevant to schizophrenia complement, and have to a large extent supplanted, pharmacological and lesion-based rat models. The main attraction is that they potentially have greater construct validity; however, they share the fundamental limitations of all animal models of psychiatric disorder, and must also be viewed in the context of the uncertain and complex genetic architecture of psychosis. Some of the key issues, including the choice of gene to target, the manner of its manipulation, gene-gene and gene-environment interactions, and phenotypic characterization, are briefly considered in this commentary, illustrated by the relevant papers reported in this special issue.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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